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WikiProject Pharmacology (Rated Start-class, Mid-importance)
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WikiProject Psychoactive and Recreational Drugs    (defunct)
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This article needs to either find references or have the uncited statements removed (which would reduce it to three or four sentences...) (talk) 11:00, 27 June 2012 (UTC)

Why does this page exist? Shouldn't it be merged with Atropine?

if i'm not mistaken, small amounts of hyoscyamine were included in the active ingredients of the since discontinued otc cold preparation contac. (talk) 17:36, 1 April 2008 (UTC)

This drug is no longer made I am told. I am researching why. Bill Carey —Preceding unsigned comment added by (talk) 17:22, 5 November 2008 (UTC)

it's still being made by Aristos Pharmaceuticals --Lieutenant Colonel Frank Slade (talk) 06:59, 14 November 2008 (UTC)

Is it still being made. According to my pharmacy it has been discontinued by the manufacturer. If someone knows maybe the article could comment on why. Is it a problem with the drug or with the company? —teb728 t c 23:15, 5 June 2009 (UTC)
CVS has substituted generic hyoscyamine with HyoMax/HyoMax-SR without additional cost since the primary previous generic manufacturer Ethex was ordered to stop selling it by the FDA. I have had no problem obtaining it at CVS and have been told it is also available at Target. Hope this helps. --Lieutenant Colonel Frank Slade (talk) 03:30, 6 January 2010 (UTC)

Hyoscyamine shortage[edit]

I found some info on the hyoscyamine shortage at this bulletin from the American Society of Health-System Pharmacists. Apparently several manufacturers have discontinued their hyoscyamine products. It says, “All hyoscyamine products are unapproved.” Apparently this means unapproved for these manufacturers—not the drug generally? I wonder if this may be related to PharmaFab’s being ordered to stop producing several drugs including hyscyamine in 2007 because they were not produced according to current good manufacturing practice requirements. —teb728 t c 19:32, 6 June 2009 (UTC)

06:14, 1 January 2012 (UTC)06:14, 1 January 2012 (UTC)H20bunny (talk) 06:14, 1 January 2012 (UTC) As of 2011, there shouldn't be any issues with obtaining hyoscyamine sulfate. I can't specify which manufacturers are still producing it, but I know there are at least 3 as I have seen three separate tablet styles over the year.

H20bunny (talk) 06:14, 1 January 2012 (UTC)

Hyoscyamine use for neuropathic pain?[edit]

In 'Uses', it says "It may be useful in pain control for neuropathic pain treated with opioids as it increases the level of analgesia obtained." There is no cite for this and I am having problems finding any additional info to back this up.
My mother suffers from non-diabetic neuropathy and is taking oxycodone. I was thinking that this might be a drug which could be added to it, but I have doubts about the accuracy of this use.
Unless someone can find a reliable source for this claim, I suggest that the second part of the "uses" section be removed and my mom's just going to have to deal with the pain. I don't want to try what could be a useless and/or harmful drug. --Jctoad (talk) 22:39, 14 December 2011 (UTC)

I wouldn't recommend taking hyoscyamine sulfate in addition to narcotics due to the very common side effect of constipation from each of the drugs. This can be compounded when taken together, and elderly patients have difficulty with bowel movements anyway, so the side effect to benefit ratio often makes it no worth taking the drugs. There are other options for neuropathy which would be much better than hyoscyamine in my opinion. — Preceding unsigned comment added by H20bunny (talkcontribs) 07:56, 1 January 2012 (UTC)

Someone needs to adapt this chart for this article[edit]

It would be nice if someone adapted this chart for this article and just take out the scopolamine part. 2602:306:C518:62C0:290F:5E4E:7E60:2AD6 (talk) 13:20, 21 July 2012 (UTC)

Actually I think the same charts can be used for both since it is specifically mentioned in the biosynthesis section that hyoscyamine is a precursor of scopolamine. So I have added a new version of the chart that while not as fancy, it is much more legible. Boghog (talk) 13:50, 19 November 2016 (UTC)

Hyoscyamine and BP[edit]

The article under pharmacology says that hyoscyamine lowers blood pressure. I'm not entirely sure if this may be true or not. BP isn't mentioned in the reference for that statement, and my research suggests it may be the opposite. After all, if BP = CO * SVR, and hyoscyamine increases CO and HR, it should increase BP rather than lower it. Thoughts? -Devanshu V (talk) 20:07, 17 July 2014 (UTC)

Identical with atropine?[edit]

According to the chemical formulas, models, and other stats, these two compounds are identical. Is it possible we actually have two articles describing the same substance?

Riventree (talk) 09:09, 9 May 2017 (UTC)
The article states that it is an optical isomer of atropine.JSR (talk) 13:21, 9 May 2017 (UTC)